PHY-OS Bone sarcoma and remodeling of calcified tissues (INSERM UMR 1238 )
October 2016
to November 2019
Using new drugs and RNA interference (si/shRNA) to target cellular stress proteins in bone cancer (Osteosarcoma)
Evaluating the effects of gene inhibition on cell processes (proliferation, death, migration, drug resistance...)
Working directly with bioinformaticians to find new therapeutic targets in bone cancer (high throughput experiments : RNA-sequencing, ChIP-sequencing, RPPA and RIME)
Studying the effects of gene inhibition on tumor growth in murine models (tumor cells injection, tumor volume monitoring, sacrifice, tumor characterization by immunohistochemistry)
Wrote an article (first author) on the inhibition of the MTH1 (NUDT1) enzyme in Osteosarcoma, and its therapeutic effects
Wrote a chapter in a published book, a protocole describing the good practice for gene expression analysis (from RNA extraction to primer design and qPCR)
First author in an yet unpublished study on the transcriptionnal network of the HSF1 trascription factor in Osteosarcoma
