Parasitology PhD @ Institut de Recherche Biologique des Armées

Présentation

PhD in Human Transmissible and Tropical Diseases, I am highly interested in the analysis of mechanisms involved in host-pathogen interactions but also drug therapy to cure infections.
I lead two projects about new therapeutic approach for severe malaria (precisely : cerebral malaria). With different skills in molecular and cellular biology animal experimentation acquired in various institutes such as Pasteur , Cochin or René Descartes University of Medecine, I have developed a real sense for human relationships. Rigorous and precise on my job, I appreciate scientifics exchanges such as laboratory meetings or work presentation.

Speciality : DNA extraction, RT-PCR, PCR, construction of vectors, DNA chips, transfection, transfection, electroporation, parasites cultured in vitro & in vivo, immunodetection (Western blot, ELISA), cell fractionation, co-immunoprecipitation, pull down, protein expression in bacteria and purification of proteins, cytokine assay (Luminex ®), Clinical follow-up and behavioral rodents (mice), pharmacological dosage collection of parasites, parasitic assessments, dissections, Pack Office, Endnote, logiciel R, Tmev, DAVID online, Graph Pad, MikroWin, Adobe Photoshop CS2 and CS5
MEETINGS AND SCIENTIFIC COMMUNICATIONS

Sep. 2012 - 17ème Actualités du Pharo, France (poster anglais)
Nov. 2012 - 32ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse, France
(oral français)
Jun. 2012 - Institut de Recherche Biologique des Armés/ Journée des Thésards, France
(poster et oral francais)
Juin 2011 - Institut de Recherche Biologique des Armés/ Journée des Thésards, France
(poster français)
Juin 2011 - 19ème Colloque de l'Ecole Doctorale des Sciences de la Vie et de la Santé, France
(poster et oral anglais)

CV réalisé sur DoYouBuzz

Expériences

PhD. Student
Institut de Recherche Biomédicle du Service de Santé des Armées
Principal Investigator: Dr. B. Pradines
other Investigators : Dr. S. Briolant, Dr N. Taudon
Statins and Malaria
Management
° Technical mentoring of an UIT student.
° Collaboration with bio-informaticians/statisticians of the TAGC lab in Luminy, France – Pr. P. Rihet
° Collaboration with Pharmacochimistry & Pharmacology unit for development (PHARMA-DEV) IRD UMR - Toulouse, France
1: Dormoi J, Savini H, Amalvict R, Baret E, Pradines B. In vitro interaction of
lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum. Malar
J. 2014 May 25;13(1):189. doi: 10.1186/1475-2875-13-189. PubMed PMID: 24886347;
PubMed Central PMCID: PMC4045961.

2: Desgrouas C, Desbordes M, Dormoi J, Ollivier E, Parzy D, Taudon N.
Quantitative analysis of cepharanthine in plasma based on semiautomatic
microextraction by packed sorbent combined with liquid chromatography. J Anal
Methods Chem. 2014;2014:695231. doi: 10.1155/2014/695231. Epub 2014 Feb 16.
PubMed PMID: 24693462; PubMed Central PMCID: PMC3945228.

3: Desgrouas C, Dormoi J, Chapus C, Ollivier E, Parzy D, Taudon N. In vitro and
in vivo combination of cepharanthine with anti-malarial drugs. Malar J. 2014 Mar
12;13(1):90. doi: 10.1186/1475-2875-13-90. PubMed PMID: 24618129; PubMed Central
PMCID: PMC3995655.

4: Ibrahim N, Ibrahim H, Dormoi J, Briolant S, Pradines B, Moreno A, Mazier D,
Legrand P, Nepveu F. Albumin-bound nanoparticles of practically water-insoluble
antimalarial lead greatly enhance its efficacy. Int J Pharm. 2014 Apr
10;464(1-2):214-24. doi: 10.1016/j.ijpharm.2014.01.001. Epub 2014 Jan 8. PubMed
PMID: 24412521.

5: Dormoi J, Briolant S, Pascual A, Desgrouas C, Travaillé C, Pradines B.
Improvement of the efficacy of dihydroartemisinin with atorvastatin in an
experimental cerebral malaria murine model. Malar J. 2013 Aug 30;12:302. doi:
10.1186/1475-2875-12-302. PubMed PMID: 23988087; PubMed Central PMCID:
PMC3765719.

6: Dormoi J, Pradines B. Dose responses of proveblue methylene blue in an
experimental murine cerebral malaria model. Antimicrob Agents Chemother. 2013
Aug;57(8):4080-1. doi: 10.1128/AAC.00634-13. Epub 2013 May 13. PubMed PMID:
23669389; PubMed Central PMCID: PMC3719760.

7: Dormoi J, Briolant S, Desgrouas C, Pradines B. Efficacy of proveblue
(methylene blue) in an experimental cerebral malaria murine model. Antimicrob
Agents Chemother. 2013 Jul;57(7):3412-4. doi: 10.1128/AAC.02381-12. Epub 2013 Apr
22. PubMed PMID: 23612202; PubMed Central PMCID: PMC3697377.

8: Dormoi J, Briolant S, Desgrouas C, Pradines B. Impact of methylene blue and
atorvastatin combination therapy on the apparition of cerebral malaria in a
murine model. Malar J. 2013 Apr 15;12(1):127. [Epub ahead of print] PubMed PMID:
23587099; PubMed Central PMCID: PMC3637457.

9: Dormoi J, Pascual A, Briolant S, Amalvict R, Charras S, Baret E, Huyghues des
Etages E, Feraud M, Pradines B. Proveblue (methylene blue) as an antimalarial
agent: in vitro synergy with dihydroartemisinin and atorvastatin. Antimicrob
Agents Chemother. 2012 Jun;56(6):3467-9. doi: 10.1128/AAC.06073-11. Epub 2012 Mar
5. PubMed PMID: 22391526; PubMed Central PMCID: PMC3370790.

10: Souraud JB, Briolant S, Dormoi J, Mosnier J, Savini H, Baret E, Amalvict R,
Soulard R, Rogier C, Pradines B. Atorvastatin treatment is effective when used in
combination with mefloquine in an experimental cerebral malaria murine model.
Malar J. 2012 Jan 10;11:13. doi: 10.1186/1475-2875-11-13. PubMed PMID: 22233563;
PubMed Central PMCID: PMC3278339.

11: Parquet V, Henry M, Wurtz N, Dormoi J, Briolant S, Gil M, Baret E, Amalvict
R, Rogier C, Pradines B. Atorvastatin as a potential anti-malarial drug: in vitro
synergy in combinational therapy with quinine against Plasmodium falciparum.
Malar J. 2010 May 25;9:139. doi: 10.1186/1475-2875-9-139. PubMed PMID: 20497586;
PubMed Central PMCID: PMC2882376..

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jerome dormoi

LOOKING FOR COLLABORATIONS IN ANIMAL TESTING IN FRANCE AND ABROAD

Parasitology PhD