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Chee-Yuen Gan

Chee-Yuen Gan

Assoc. Prof. Dr.

Academic
Research
Laboratory service
Quality management
Science consultant
42 years old
Penang (11800) Malaysia
Employed Available
Contact me
Currently, I am working as a Deputy Director in Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia. Previously given administrative and technical responsibilities are: Deputy Technical Manager (in food safety testing, drug of abuse testing, elemental testing) as well as Quality Manager (ISO/IEC17025). I have over 6 years of experience in Academic and Research Sector and 1 year as Post-doctorate fellow. Also, I am a proactive academician and researcher with expertise in the research field of analytical chemistry and food chemistry. I managed to publish 43 international journals and actively involved as reviewers (reviewed over 200 articles) for the past 6 years and successfully secure several research grants including ERGS, RU and private grants. I am also professionally recognized as science consultants.
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Experiences
  • Deputy Director - Analytical Biochemistry Research Centre (ABrC)
  • Deputy technical manager - Centre for Advanced Analytical Toxicology Services (CAATS), which involved in developing new methods for routine services
  • Quality Management (as Quality Manager and Committee of the quality management team) and successfully retain the ISO/IEC 17025 from the National Association of Testing Authorities, Australia (NATA)
  • Head of department for proteomics and natural product discovery laboratory, as well as post graduate studies in Doping Control Centre (DCC)
  • Signatory - to approve the results from the routine services
  • Gan, C.Y., Cheng, L.H., & Easa, A.M. (2008). Physicochemical properties and microstructures of soy protein isolate gels produced using combined cross-linking treatments of microbial transglutaminase and Maillard cross-linking. Food Research International, 41(6): 600-605.
  • Gan, C.Y., Cheng, L.H., & Easa, A.M. (2008). Evaluation of Microbial Transglutaminase and Ribose Cross-linked Soy Protein Isolate-based Microcapsules Containing Fish Oil. Innovative Food Science and Emerging Technologies, 9(4): 563-569.
  • Gan, C.Y., Cheng, L.H., & Easa, A.M. (2009). In-vitro digestibility and amino acid composition of soy protein isolate cross-linked with microbial transglutaminase followed by heating with ribose. International Journal of Food Sciences and Nutrition 60, 99-108
  • Gan, C.Y., AlKharkhi, A.F.M. & Easa, A.M. (2009). Using response surface methodology to optimize process parameters and cross-linking agents for production of combined-crosslinked bovine serum albumin gels. Journal of Bioscience and Bioengineering, 107: 366-372.
  • Gan, C.Y., Cheng, L.H., & Easa, A.M. (2009). Assessment of Maillard
    reaction and cross-linking in transglutaminase-cross-linked powdered soy protein isolate gel. Journal of Food Science, 74(2): C141-C146.
  • Gan, C.Y., Ong, W.H., Wong, L.M., & Easa, A.M. (2009). Effects of ribose, microbial transglutaminase and soy protein isolate on physical properties and in-vitro starch hydrolysis of yellow noodles. LWT-Food Science and Technology, 42(1): 174-179.
  • Gan, C.Y., Cheng, L.H., Phuah, E.T., Chin, P.N., AlKharkhi, A.F.M. & Easa, A.M. (2009). Combined cross-linking treatments of bovine serum albumin gel beadlets for controlled- delivery of caffeine. Food Hydrocolloids, 23: 1398-1405.
  • Gan, C.Y., Latiff, A.A., Cheng, L.H., & Easa, A.M. (2009). Gelling of microbial transglutaminase cross-linked soy protein in the presence of ribose and sucrose. Food Research International, 42:1373-1380.
  • Gan, C.Y., Abdul Manaf, N., & Latiff, A.A. (2010). Optimization of alcohol insoluble polysaccharides (AIPS) extraction from the Parkia speciosa pod using response surface methodology (RSM). Carbohydrate Polymers, 79, 825-831.
  • Gan, C.Y., Abdul Manaf, N., & Latiff, A.A. (2010). Physico-chemical properties of alcohol precipitate pectin-like polysaccharides from Parkia speciosa pod. Food Hydrocolloids, 24: 471-478.
  • Gan, C.Y., & Latiff, A.A. (2011). Optimization of the solvent extraction of bioactive compounds from Parkia speciosa pod using response surface methodology. Food Chemistry, 124: 1277-1283.
  • Gan, C.Y., & Latiff, A.A. (2011). Extraction of antioxidant pectic-polysaccharide from mangosteen (Garcinia mangostana) rind: Optimization using response surface methodology. Carbohydrate Polymers, 83: 600-607
  • Gan, C.Y., & Latiff, A.A. (2011). Antioxidant Parkia speciosa pod powder as potential functional flour in food application: Physico-chemical properties characterization. Food Hydrocolloids, 25: 1174-1180.
  • Abedin, M.Z, Karim, A.A., Ahmed, F., Latiff, A.A, Gan, C.Y., Ghazali, F.C., & Sarker M.Z.I (2013). Isolation and characterization of pepsin-solubilized collagen from the integument of sea cucumber (Stichopus vastus). Journal of Science and Food Agriculture, 93(5); 1083-1088
  • Lew, L.C., Liong, M.T., & Gan, C.Y. (2012). Growth optimization of Lactobacillus rhamnosus FTDC 8313 and the production of putative dermal bioactives in the presence of manganese and magnesium ions. Journal of Applied Microbiology, 114(2): 526-535
  • Lew, L.C., Gan, C.Y., & Liong, M.T. (2012). Derma bioactives from lactobacilli and bifidobacteria. Annals of Microbiology, 63(3): 1047-1055
  • Siow, H.L. & Gan, C.Y. (2013). Extraction of antioxidative and antihypertensive bioactive peptides from Parkia speciosa seeds. Food Chemistry, 141: 3435-3442
  • Tan, C.C. Abdul Karim, A., Aishah, A.A, & Gan, C.Y. (2013). Extraction and characterization of pepsin-solubilized collagen from the body wall of crown-of-thorns Starfish (Acanthaster planci). International Food Research Journal, 20(6): 3013-3020
  • Abedin, M.Z., Karim, A.A., Latiff, A.A., Gan, C.Y., Ghazali, F.C., Zzaman, M., Hossain, M.M., Ahmed, F., Absar, N., & Sarker, M.Z.I. (2013). Physicochemical and biochemical properties of pepsin-solubilized collagen isolated from the integument of sea cucumber (Stichopus vastus). Journal of Food Processing and Preservation, 38(4):2027-2036
  • Barzideh, Z., Karim, A.A., Latiff, A.A., Gan, A.A., Benjakul, S. (2014). Isolation and Characterization of Collagen from the Ribbon Jellyfish (Chrysaora sp.). International Journal of Food Science and Technology, 49:1490-1499.
  • Tan, E.S, Ngoh, Y.Y. & Gan, C.Y.(2014) A comparative study of physicochemical characteristics and functionalities of pinto bean protein isolate (PBPI) against the soybean protein isolate (SPI) after the extraction optimization. Food Chemistry 152: 447-455
  • Tan, P.L., Peh, K.K., Gan, C.Y., Liong, M.T. (2014). Bioactive dairy ingredient for food and non-food applications. Acta Alimentaria, 43(1): 113-123.
  • Leong, Y.H., Chiang, P.N., Jaafar, H.J., Gan, C.Y., Abd Majid, M.I. (2014). Contamination of food samples from Malaysia with polychlorinated dibenzo-p-dioxins and dibenzofurans and estimation of human intake. Food Additive and Contaminants: Part A. 31(4), 711-718
  • Leong, Y.H., Gan, C.Y., Tan, M.A.F., Abd Majid, M.I. (2014). Present Status and Future Concerns of Expanded Newborn Screening in Malaysia: Sustainability, Challenges and Perspectives. Malays J Med Sci. Mar-Apr 2014; 21(2): 64-68
  • Leong, Y.H., Gan, C.Y., Abd Majid, M.I. (2014). Dioxin-Like Polychlorinated Biphenyls, Polychlorinated Dibenzop-Dioxins, and Polychlorinated Dibenzofurans in Seafood Samples from Malaysia: Estimated Human Intake and Associated Risks. Arch Environ Contam Toxicol. 67(1), 21-28
  • Leong, Y.H., Chiang, P.N., Jaafar, H.J., Gan, C.Y., Abd Majid, M.I. (2014). Occurrence and Dietary Intake of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Malaysia. In: From Sources to Solution. Proceedings of the International Conference on Environmental Forensic 2013, Chapter 10, (Azis et al. eds). Pp. 49-53.
  • Abedin, M.Z., Karim, A.A., Latiff, A.A., Gan, C.Y., Ghazali, F.C., Barzideh, Z., Ferdosha, S., Akandaa, M.J.H., Zzaman, M., Karime, M.R. & Sarker, M.Z.I. (2014). Biochemical and radical-scavenging properties of sea cucumber (Stichopus vastus) collagen hydrolysates. Natural Product Research 28(16),1302-1305.
  • Siow, H.L., Gan C.Y. (2014). Functional protein from cumin seed (Cuminum cyminum): Optimization and characterization studies. Food Hydrocolloids 41: 178-187.
  • Barzideh, Z., Latiff, A.A., Gan, A.A., Abedin, M.Z., Karim, A.A. (2014). ACE inhibitory and antioxidative activities of collagen hydrolysates from the ribbon jellyfish (Chrysaora sp.). Food Technology and Biotechnology, 49, 1490-1499.
  • Barzideh, Z., Latiff, A.A., Gan, A.A., Abedin, M.Z., Karim, A.A. (2014).Functional properties of collagen hydrolysates from the jellyfish (Chrysaora sp.). Agro Food Industry Hi Tech, 25(4): 27-32
  • Chin, C.F., Tan, S.J., C.Y. Gan, & Lim, T.S. (2015). Identification of peptide based inhibitors for α-amylase by phage display. International Journal of Peptide Research and Therapeutics, 21(3): 237-242
  • Gan C.Y., Kee S.M., Chiang P.N. (2015). Extraction and Identification of Antidiabetic and Antioxidative Phytochemicals from Pisang awak Leaves. International Journal of Pharmacognosy and Phytochemical Research 2015; 7(3); 461-472
  • Ngoh, Y. Y., Leong, Y.-H. and Gan, C. Y. (2015). Optimization study for synthetic dye removal using an agricultural waste of Parkia speciosa pod: A sustainable approach for waste water treatment. International Food Research Journal 22(6): 2351-2357
  • Abedin, M. Z., Karim, A. A., Gan, C.Y., Ghazali, F. C., Barzideh, Z., Zzaman, W. and Zaidul, I. S. M. (2015). Identification of angiotensin I converting enzyme inhibitory and radical scavenging bioactive peptides from sea cucumber (Stichopus vastus) collagen hydrolysates through optimization. International Food Research Journal 22(3): 1074-1082
  • Liew WPP, Ong JS, Gan CY, Yahaya S, Khoo BY, Liong MT (2015) Gut Microbiome and Stress. In: MT Liong (Ed), Beneficial Microoorganisms in Medical and Health Applications, vol. 28, pp. 223-255, Springer International Publishing, Switzerland
  • Loh YS, Lew LC, Khoo BY, Khalil NA, Gan CY, Liong MT (2015) Roles of Probiotics on Lifelong Diversifications of Gut Microbiota. In: MT Liong (Ed), Beneficial Microorganisms in Food and Nutraceuticals, vol 27, pp. 245-263, Springer International Publishing, Switzerland
  • Nurul Hidayatul Afifah B. S..S. & Gan C.Y. (2016). Antioxidative and amylase inhibitor peptides from Basil seeds. International Journal of Peptide Research and Therapeutics, 22: 3-10
  • Ngoh, Y.Y. & Gan C.Y. (2016). Enzyme-assisted extraction and identification of antioxidative and a-amylase inhibitory peptides from Pinto beans (Phaseolus vulgaris cv. Pinto). Food Chemistry, 190 331–337
  • Tan, H.F. & Gan C.Y. (2016). Polysaccharide with antioxidant, α-amylase inhibitory and ACE inhibitory activities from Momordica charantia. International Journal of Biological Macromolecules, 85: 487-496
  • Siow, H.L. & Gan C.Y. (2016). Extraction, identification, and structure–activity relationship of anti-oxidative and α-amylase inhibitory peptides from cumin seeds (Cuminum cyminum). Journal of Functional Food, 22, 1-12.
  • Kamarudin, F. & Gan, C.Y. (2016). Molecular structure, chemical properties and biological activities of Pinto bean pod polysaccharide. International Journal of Biological Macromolecules, 88: 280-287
  • Ngoh, Y.Y., Lim, T.S., & Gan, C.Y. (2016). Screening and Identification of Five Peptides from Pinto Bean with Inhibitory Activities against α-Amylase using Phage Display Technique. Enzyme and Microbial Technology, 89: 76-84
  • Siow, H.L. & Gan C.Y. (2016). Optimization study in extracting anti-oxidative and α-amylase inhibitor peptides from cumin seeds (Cuminum cyminum). Journal of Food Biochemistry. Doi: 10.1111/jfbc.12280
  • Siow, H.-L., Choi, S.-B.,Gan, C.-Y. (2016) Structure–activity studies of protease activating, lipase inhibiting, bile acid binding and cholesterol-lowering effects of pre-screened cumin seed bioactive peptides. Journal of Functional Foods, 27: 600-611
  • Murugan, P., Han, L., Gan, C.-Y., Maurer, F.H.J.,Sudesh, K. (2016). A new biological recovery approach for PHA using mealworm, Tenebrio molitor. Journal of Biotecjnology, 239: 98-105
  • Park, Y.H., Hamidon, F., Rajangan, C., Soh, K.P., Gan, C.Y., Lim, T.S., Wan Abdullah, W.N., Liong, M.T. (2016). Application of Probiotics for the Production of Safe and High-quality Poultry Meat, Korean Society for Food Science of Animal Resources, 36 (5): 567-576
  • Siow, H.L., Lim, T.S. & Gan, C.Y. (2017). Development of a aworkflow for screening and identification of α-amylase inhibitory peptides from food source using an integrated Bioinformatiics-phage display approach: Case study – Cumin seed. Food Chemistry, 214: 67-76
  • International journal reviewers (over 200 manuscripts)
  • Editor and associate editor for the International Journal of Environmental Science and Toxicology and International Journal Network, respectively
  • Invited speaker at the symposium and conferences
  • Science consultant for private companies
  • Technical assessor for ISO/IEC 17025 by SAMM (National Laboratory Accreditation Scheme)
  • Stock Option by Holista CollTech. Ltd. RM 300,000
  • Sanggar Sanjung Award (2009-2015), Universiti Sains Malaysia
  • Persada Kencana Award (2009), Universiti Sains Malaysia
  • Alumni Persada Kencana Award (2009), Universiti Sains Malaysia
  • Exhibitor, Chee-Yuen Gan (2011) OvinexTM the premium sheep collagen. Malaysia Technology Expo, 17-19 February, Kuala Lumpur Convention Center, Malaysia, Silver medal winner
  • Exhibitor, Chee-Yuen Gan (2011) Ovinex the premium sheep collagen. BioMalaysia 2011, 21-23 November, Kuala Lumpur Convention Center, Malaysia, Gold medal winner
  • Exhibitor, Chee-Yuen Gan (2014). Parkia BioPep. Malaysia Technology Expo, 19-21 February, PWTC, Malaysia, Bronze medal winner
  • Presenter, Hooi-Ling Liew, Aishah A. Latiff, Michael Harvey, Chow-Yang Lee, Chee-Yuen Gan (2010) Characterization of potentially bioactive peptide and small molecules in Tetraponera Rufonigra using HLPC-Chip Cube-Accurate Mass Q-TOF MS and MS/MS. 58th ASMS Conference on Mass Spectrometery and Allied Topics, 22-27 May 2010, Salt Palace Convention Centre, Salt Lake City, United State
  • Presenter, Kim-Siew Yap, Aishah A. Latiff, Shahrul Anuar Mohd Shah, Chee-Yuen Gan (2010) Characterization of proteins contained in skin secretions of Phrynoidis Aspera. ASMS Conference on Mass Spectrometery and Allied Topics, 22-27 May 2010, Salt Palace Convention Centre, Salt Lake City, United State
  • Speaker, Chee-Yuen Gan, Aishah A. Latiff, Keat-Teong Lee (2010) A simultaneous processing of natural product and bioethanol as zero-waste management of lignocellulosic biomass. Conference Venice 2010: Third International Symposium on Energy from Biomass and Waste, 8-11 Nov 2010, Cini Foundation, Venice, Italy
  • Invited speaker, Chee-Yuen Gan (2010) Innovation on collagen. BioMalaysia 2010, 1-3 Nov 2010, Kuala Lumpur Convention Center, Malaysia
  • Invited speaker, Chee-Yuen Gan (2011) Prediction of metabolites in methanolic crude extract from Parkia speciosa using LCMS Q-TOF followed by Metlin metabolite database search. Total Agilent Experience Science Symposium, 23-24 May, Kuala Lumpur, Malaysia
  • Presenter, Erna Ahmad, Masturah Mohd Narawi, Mohd Adi Firdaus Tan Abdullah, Chee-Yuen Gan (2012). Enzymatic-mediated extraction of pectic-polysaccharide from Theobroma cacao pod. 3rd International Conference on Environmental Research and Technology (ICERT 2012), 31 May – 3 June 2012, Penang
  • Presenter, Gan Chee Yuen, Mohd Nazri Ismail, Fazilah Othman, Nurul Nabilah Zainudin, Aishah A. Latiff (2012). Characterization of the proteomic and glycomic contents of hevea brasiliensis latex. Conference for American Society of Mass Spectrometry 2012, 20-24 May 2012, Canada
  • Presenter, Zoha Barzideh, Abd Karim Alias, Aishah Abd Latiff, Gan Chee Yuen, (2012). Isolation and charachterization of collagen from ribbon jellyfish (Chrysaora sp.). International Conference on Halal Gums 2012 (ICoHaG 2012), 5-7 December 2012, Penang
  • Exhibitor, BioInnovation Award, 2014, Gan Chee Yuen,Siow Hwee Leng, Tan Sze Jack, Ngoh Ying Yuan, Parkia-BioPep, Protemp and Malaysia Association of Research Scientists, Kuala Lumpur, silver medal
  • Presenter, 13. Tan, S.J & Gan, C.Y.(2015). Physico-chemical characterization of antioxidant pectic-polysaccharide from mangosteen (Garcina mangostana) rind. 15th International Nutrition & Diagnostics Conference Proceedings, , 5-8 Oct 2015, Prague, Czech Republic, p 113
  • Presenter, 14. Siow, H.L. & Gan, C.Y. (2015). Cumin seed (Cuminium cyminum), an alternative source of antioxidative and antidiabetic bioactive peptides. 15th International Nutrition & Diagnostics Conference Proceedings, , 5-8 Oct 2015, Prague, Czech Republic, p 114
  • Presenter, 15. Ngoh, Y.Y. & Gan, C.Y. (2015). A workflow on the production of bioactive peptides from food sources based on the case study using Pinto beans (Phaseolus vulgaris cv. Pinto). 15th International Nutrition & Diagnostics Conference Proceedings, 5-8 Oct 2015, Prague, Czech Republic, p 115
  • Principal Investigator:
    1. Halal Ovine Collagen - Holista Biotech Sdn. Bhd., HOLISTA BIOTECH SDN. BHD., RM26,836.09, 17/9/2009-31/12/2013
    2. A Sustainable Route for Waste Management of Cocoa Lignocellulosic Biomass: Development of a Simultaneous Extraction-Conversion Processing Line as the Protocol Prior to Bio-Refinery, USM (Short term), RM39,980.00, 15/6/2012-14/12/2014
    3. Development of electropulsation for the extraction of protein from underutilized agro-source, pinto bean, as an alternative solution to the issue of protein-malnutrition, KEMENTERIAN PENGAJIAN TINGGI (ERGS Grant), RM115,000.00, 1/6/2013-30/11/201
    4. Enzyme-Assisted Extraction And Identification Of Antidiabetic Bioactive Peptides From Basil Seeds, USM (RU), RM197,205.53, 1/3/2015-28/2/2017
    5. Novel Advanced natural Materials: From Agrowaste: Phytochemicals And Polysaccharides, USM (RU), RM78,000.00, 15/12/2009-14/12/2011
    6. Extraction Optimization and Characterization of Antihypertensive and Antioxidative Phytochemicals from Banana Leaves in Malaysia, USM (Short Term), RM34,883.40, 1/11/2014-31/10/2016
  • Co-reseearcher:
    1. The Correlation For Dioxins And Dioxin-Like PCBs Exposure Among Breastfeeding Mothers In Malaysia To The Environmental Contamination Levels, USM (RU), RM100,000.00, 31/12/2014-31/12/2016
    2. Marine Microalgae-An Alternative Feedstock For Bioplastics Production, USM (RU), RM198,233.00, 31/12/2014-31/12/2017
    3. Investigation of the Efficacy of Banana Leaves Extract in Antifungal and Aflatoxin Inhibition Properties, USM (Short Term), RM38,011.90, 1/6/2015-31/5/2017
    4. The Profiling of Ketum (Mitragyna Speciosa) Abusers in the State of Kedah Malaysia and the Confirmation of Mitragynine in the Urine of Ketum Abusers, USM (Short Term), RM33,000.00, 1/4/2016-31/3/2018
Portfolios

Development of a aworkflow for screening and identification of α-amylase inhibitory peptides from food source using an integrated Bioinformatiics-phage display approach: Case study – Cumin seed. Food Chemistry, 214: 67-76.

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Optimization study in extracting anti-oxidative and α-amylase inhibitor peptides from cumin seeds (Cuminum cyminum). Journal of Food Biochemistry. Doi: 10.1111/jfbc.12280

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Screening and Identification of Five Peptides from Pinto Bean with Inhibitory Activities against α-Amylase using Phage Display Technique. Enzyme and Microbial Technology, 89: 76-84

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Molecular structure, chemical properties and biological activities of Pinto bean pod polysaccharide. International Journal of Biological Macromolecules, 88: 280-287

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Extraction, identification, and structure–activity relationship of anti-oxidative and α-amylase inhibitory peptides from cumin seeds (Cuminum cyminum). Journal of Functional Food, 22, 1-12.

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Skills

Research

  • Peptidomics
    Expert
  • Proteomics
    Advanced
  • Bioactive polysaccharide
    Advanced
  • Analytical chemistry
    Advanced
  • Enzyme technology
    Advanced

Teaching

  • Enzyme technology - immobilization and applications of enzyme
  • Analytical analyses - instrumental and chemical analyses

Management

  • Quality management - ISO 17025
Interests

Research Collaboration

  • Bioactive peptides and polysaccharides
  • Mass spectrometry analysis development

Training

  • Mass spectrometry
  • Metabolomics
  • Proteomics
  • Peptidomics
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